Investigating the effects of sulforaphane on chronic kidney disease
Safety, Feasibility and Efficacy of Sulforaphane in Chronic Kidney Disease
This study is looking at whether a natural compound from broccoli called sulforaphane can help improve kidney health for people with chronic kidney disease who have a certain genetic trait that might make their condition worse.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10676994 on NIH RePORTER |
What this research studies
This research explores how sulforaphane, a compound found in cruciferous vegetables like broccoli, may help reduce oxidative stress in patients with chronic kidney disease (CKD). The study focuses on individuals with a specific genetic variant that affects their antioxidant enzyme activity, potentially leading to faster CKD progression. By supplementing with sulforaphane, the research aims to assess its safety, feasibility, and effectiveness in improving kidney health. Participants will be monitored for changes in kidney function and oxidative stress levels throughout the study.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with chronic kidney disease, particularly those with the GSTM1 null allele variant.
Not a fit: Patients without chronic kidney disease or those who do not carry the GSTM1 null allele may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new dietary intervention to slow the progression of chronic kidney disease.
How similar studies have performed: Previous studies have shown that dietary intake of cruciferous vegetables is associated with lower risks of kidney failure, suggesting potential success for this approach.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Le, Thu H. — University of Rochester
- Study coordinator: Le, Thu H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.