Investigating the effects of SCN2A gene deficiency on behavior in autism spectrum disorder.
Neuronal and Behavioral Deficits Associated with Scn2a Deficiency in Autism Spectrum Disorder
['FUNDING_R01'] · PURDUE UNIVERSITY · NIH-11061109
This study is looking at how a missing piece of the SCN2A gene affects brain function and behavior in people with autism, using mice to see if changing brain activity can help improve social skills and reduce anxiety.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PURDUE UNIVERSITY (nih funded) |
| Locations | 1 site (WEST LAFAYETTE, UNITED STATES) |
| Trial ID | NIH-11061109 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how a deficiency in the SCN2A gene affects neuronal function and behavior in individuals with autism spectrum disorder (ASD). Using a specially designed mouse model, the study will explore the relationship between neuronal activity in the medial prefrontal cortex and behavioral outcomes, particularly social interactions and anxiety-like behaviors. The researchers aim to manipulate the balance of excitation and inhibition in the brain to see if it can improve behavioral deficits associated with SCN2A deficiency. This approach may lead to new insights into potential therapeutic interventions for ASD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder, particularly those with known SCN2A gene deficiencies.
Not a fit: Patients without autism spectrum disorder or those whose conditions are not linked to SCN2A deficiencies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted treatments that improve social and behavioral functioning in individuals with autism spectrum disorder.
How similar studies have performed: Other research has shown promising results in understanding the role of genetic factors in autism, but this specific approach using SCN2A deficiency is relatively novel.
Where this research is happening
WEST LAFAYETTE, UNITED STATES
- PURDUE UNIVERSITY — WEST LAFAYETTE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANG, YANG — PURDUE UNIVERSITY
- Study coordinator: YANG, YANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.