Investigating the effects of repeated influenza vaccinations on immune responses.
Official title: Does repeated influenza vaccination constrain influenza immune responses and protection?
Funded at University of Melbourne · NIH-10676095 · Data updated 2026-11-12
This study is looking at how getting the flu shot every year affects the immune system of healthcare workers, to see if frequent vaccinations might make it harder for their bodies to fight off the virus, with the goal of finding better ways to protect everyone from the flu.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Melbourne NIH-funded |
| Lab location | 1 site (Melbourne, Australia) |
| Project start | July 3, 2019 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $129,250 |
| NIH project number | 5R01AI141534-05 |
| Project ID | NIH-10676095 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are healthcare workers who receive annual influenza vaccinations.
✕Less likely to help
Patients who do not work in healthcare settings or those who do not receive influenza vaccinations may not benefit from this research.
What this research studies
This research examines how repeated influenza vaccinations impact the immune responses of healthcare workers, a group that is often required to receive these vaccines. By analyzing the immunogenicity and effectiveness of the vaccines over time, the study aims to understand whether frequent vaccinations may weaken the body's ability to respond effectively to the virus. The research employs statistical and mathematical modeling to explore the immunological processes involved, which could lead to improved vaccination strategies. Participants will be monitored for their immune responses and overall health outcomes related to influenza.
Why it matters
Potential benefit: If successful, this research could lead to more effective influenza vaccination strategies, enhancing protection for healthcare workers and their patients.
How similar studies have gone: While there is emerging evidence regarding the effects of repeated vaccinations, this research aims to provide comprehensive long-term data, making it a novel approach in this area.
Where this research is happening
-
University of Melbourne
Melbourne, Australia Active
Researchers
- Principal investigator: Fox, Annette — University of Melbourne
- Study coordinator: Fox, Annette
Related research
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-
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.