Investigating the effects of reduced nicotine cigarettes and e-cigarettes on dual tobacco users
Official title: A randomized controlled trial of reduced nicotine cigarettes and e-cigarettes among dual users
Funded at University of Vermont & St Agric College · NIH-11004654 · Data updated 2026-11-12
This study is looking at how lowering the nicotine in cigarettes might help people who smoke both cigarettes and e-cigarettes switch to using e-cigarettes only, which could be better for their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $777,503 |
| NIH project number | 5R01DA059562-02 |
| Project ID | NIH-11004654 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who currently use both cigarettes and e-cigarettes.
✕Less likely to help
Patients who exclusively use either cigarettes or e-cigarettes without dual use may not benefit from this research.
What this research studies
This research explores how reducing nicotine levels in cigarettes affects individuals who use both cigarettes and e-cigarettes. It aims to understand whether lowering nicotine content can help these dual users transition to using e-cigarettes exclusively, potentially reducing their overall tobacco-related health risks. Participants will be randomly assigned to different groups to evaluate their smoking behaviors and dependence levels over time. The study will also assess the appeal of e-cigarettes as an alternative to traditional cigarettes.
Why it matters
Potential benefit: If successful, this research could lead to strategies that help dual tobacco users reduce their smoking and improve their health outcomes.
How similar studies have gone: Previous studies have shown that reducing nicotine in cigarettes can lead to decreased smoking behaviors, but this specific approach with dual users is relatively novel.
Where this research is happening
-
University of Vermont & St Agric College
Burlington, United States Active
Researchers
- Principal investigator: Klemperer, Elias M — University of Vermont & St Agric College
- Study coordinator: Klemperer, Elias M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.