Investigating the effects of rapid volume resuscitation in newborns with cardiac arrest due to blood loss.
Official title: Neonatal Hypovolemic Cardiac Arrest: Role of Early Rapid Volume Resuscitation
Funded at University of California at Davis · NIH-10739265 · Data updated 2026-11-12
This study is looking at whether quickly giving extra blood to newborns who have heart problems from losing blood during birth can help them recover better than the usual slower method, and it's designed to improve care for babies in critical condition.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $160,000 |
| NIH project number | 1R03HD109443-01A1 |
| Project ID | NIH-10739265 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns who have experienced birth asphyxia and are at risk of cardiac arrest due to significant blood loss.
✕Less likely to help
Patients who are not newborns or those who do not experience birth asphyxia or related cardiac issues may not benefit from this research.
What this research studies
This research focuses on understanding how quickly replacing lost blood volume can help newborns who experience cardiac arrest due to asphyxia from fetal blood loss. The study aims to compare the effects of early rapid volume resuscitation versus the standard slower approach currently used in neonatal care. By using an ovine model, researchers will simulate conditions similar to those in newborns to gather data on how these interventions affect heart function and recovery. The goal is to improve outcomes for infants who are critically ill at birth.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and recovery outcomes for newborns experiencing cardiac arrest due to blood loss.
How similar studies have gone: While the specific approach of rapid volume resuscitation in newborns is not widely tested, similar strategies in other populations have shown promise in improving outcomes.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Sankaran, Deepika — University of California at Davis
- Study coordinator: Sankaran, Deepika
Related research
Other NIH-funded projects on the same topics.
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Multi-center study on how ventilation during CPR relates to cardiac arrest outcomes
A large, real-world study will look at how ventilation during CPR affects survival after out-of-hospital cardiac arrest in adults.
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Specialized post-arrest care after cardiac arrest
A large, nationwide effort tests whether transferring cardiac arrest patients to a specialized post-arrest care center improves recovery compared with usual care.
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Reduce bias in predicting brain recovery after cardiac arrest
This project aims to make brain-recovery predictions more accurate for people who survive cardiac arrest by comparing outcomes between the United States and Brazil.
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Fairer brain recovery predictions after cardiac arrest through U.S.–Brazil collaboration
This project aims to find better ways to predict brain recovery for people who survive cardiac arrest but have possible brain injury.
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Improving predictions of brain recovery after cardiac arrest
This project compares outcomes after cardiac arrest in the U.S. and Brazil to learn which tests best predict who will regain brain function for people who survive cardiac arrest.
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Reducing biased predictions of brain recovery after cardiac arrest
This project looks at cardiac arrest survivors in the US and Brazil to find more accurate ways to predict brain recovery and avoid premature stopping of life support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.