Investigating the effects of proton and high-LET radiation on head and neck cancer and glioblastoma
Official title: Realizing the radiobiological impact of protons and high-LET particles in head and neck cancer and glioblastoma models
Funded at University of Birmingham · NIH-11089388 · Data updated 2026-11-12
This study is looking at how different types of radiation treatments, like proton therapy and high-LET radiation, affect head and neck cancer and glioblastoma cells, with the hope of finding better ways to treat these cancers while reducing side effects for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United Kingdom) |
| Project start | July 1, 2021 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $300,832 |
| NIH project number | 5R01CA256854-05 |
| Project ID | NIH-11089388 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with head and neck cancer or glioblastoma who are considering radiotherapy as part of their treatment plan.
✕Less likely to help
Patients with cancers not located in the head and neck or brain, or those who are not candidates for radiotherapy, may not benefit from this research.
What this research studies
This research focuses on understanding how proton and high-LET radiation therapies affect head and neck cancer and glioblastoma cells. By using advanced 2D and 3D cell models that mimic actual tumors, the study aims to reveal the biological impacts of these therapies compared to traditional X-ray radiotherapy. The goal is to optimize treatment approaches to enhance effectiveness while minimizing side effects for patients undergoing radiotherapy. This collaborative effort involves experts in radiation physics, biology, and clinical oncology.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer radiation therapies for patients with head and neck cancer and glioblastoma.
How similar studies have gone: Previous research has shown promising results with proton therapy and high-LET radiation, indicating potential advancements in cancer treatment.
Where this research is happening
-
University of Birmingham
Birmingham, United Kingdom Active
Researchers
- Principal investigator: Parsons, Jason — University of Birmingham
- Study coordinator: Parsons, Jason
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.