Investigating the effects of prenatal oxycodone exposure on infants and their long-term outcomes.
Oxycodone, Neonatal Opioid Withdrawal Syndrome, and Adult Abuse Liability
This study is looking at how being exposed to oxycodone before birth affects babies who are born dependent on opioids, especially those going through withdrawal, to help us understand their development and find better ways to support them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10839468 on NIH RePORTER |
What this research studies
This research focuses on understanding how prenatal exposure to oxycodone affects infants who are born dependent on opioids, particularly those experiencing neonatal opioid withdrawal syndrome (NOWS). The study utilizes an animal model to explore the long-term neurodevelopmental impacts of oxycodone exposure, assessing changes in body weight and vocalizations in offspring. By examining these effects, the research aims to uncover potential vulnerabilities that may arise in children exposed to opioids in utero, which could inform treatment and management strategies for affected infants.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include infants born to mothers who used oxycodone during pregnancy and are experiencing withdrawal symptoms.
Not a fit: Patients who are not affected by opioid exposure during pregnancy or do not exhibit symptoms of neonatal opioid withdrawal syndrome may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of neonatal opioid withdrawal syndrome, ultimately benefiting affected infants and their families.
How similar studies have performed: While there has been some research on opioid exposure and its effects, this specific approach using an animal model of prenatal oxycodone exposure is relatively novel and has not been extensively tested.
Where this research is happening
Boston, United States
- Tufts University Boston — Boston, United States (Active)
Researchers
- Principal investigator: Byrnes, Elizabeth M — Tufts University Boston
- Study coordinator: Byrnes, Elizabeth M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.