Investigating the effects of physical stress on heart cells from muscular dystrophy patients
Official title: Physiologic stress in advanced tissue culture models of cardiomyopathy
Funded at Northwestern University at Chicago · NIH-10983739 · Data updated 2026-11-12
This study is looking at how physical stress impacts heart cells from people with muscular dystrophy, especially those with Duchenne and LMNA-related types, to help find better ways to treat heart problems they might face.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $164,052 |
| NIH project number | 5K08HL163392-03 |
| Project ID | NIH-10983739 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Duchenne muscular dystrophy or LMNA-related muscular dystrophy.
✕Less likely to help
Patients without muscular dystrophy or those with unrelated cardiac conditions may not benefit from this research.
What this research studies
This research focuses on understanding how physical stress affects heart cells derived from patients with muscular dystrophy, particularly those with Duchenne and LMNA-related muscular dystrophy. By creating advanced tissue models using patient-specific stem cells, the study aims to replicate the conditions these cells experience in the body. The researchers will apply mechanical stress to these engineered heart tissues to observe how they respond, which could lead to better therapeutic strategies for managing heart complications in these patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for heart failure and arrhythmias in patients with muscular dystrophy.
How similar studies have gone: Previous research has shown promise in using engineered heart tissues to study cardiac diseases, indicating that this approach could yield valuable insights.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Fullenkamp, Dominic Edward — Northwestern University at Chicago
- Study coordinator: Fullenkamp, Dominic Edward
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.