Investigating the effects of organophosphate exposure using advanced imaging techniques in mice
Official title: MALDI Imaging of Acute Organophosphate Exposure in KIKO Mice
Funded at Johns Hopkins University · NIH-11090463 · Data updated 2026-11-12
This study is looking at how long-term exposure to certain chemicals called organophosphates affects the brain and body, using special mice to help scientists understand the changes that might lead to problems with thinking and mood.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $463,660 |
| NIH project number | 5R01NS136102-02 |
| Project ID | NIH-11090463 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been exposed to organophosphates and are experiencing cognitive or mood-related symptoms.
✕Less likely to help
Patients who have not been exposed to organophosphates or do not exhibit any related symptoms may not benefit from this research.
What this research studies
This research focuses on understanding the long-term effects of organophosphate exposure, which affects millions globally. Using a specially designed mouse model called the KIKO mouse, researchers will explore the molecular changes that occur after exposure to these chemicals. They will employ a cutting-edge imaging technique known as MALDI mass spectrometry imaging to visualize and analyze the distribution of neurotransmitters, metabolites, and lipids in the brain and other tissues. This approach aims to uncover the underlying mechanisms of cognitive and mood disorders associated with organophosphate exposure.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for individuals suffering from cognitive and mood disorders due to organophosphate exposure.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques to study neurological effects, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Tressler, Caitlin — Johns Hopkins University
- Study coordinator: Tressler, Caitlin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.