Investigating the effects of opioid use during pregnancy on fetal and placental health
Official title: Multimodal Fetal and Placental Imaging and Biomarkers of Clinical Outcomes in Opioid Use Disorder
Funded at Indiana University Indianapolis · NIH-10750306 · Data updated 2026-11-12
This study is looking at how using opioids during pregnancy can impact the health of both the baby and the placenta, using special imaging and tests to find early signs of any problems, so we can help moms and their little ones stay healthier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $3,145,305 |
| NIH project number | 1R01DA059321-01 |
| Project ID | NIH-10750306 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include pregnant women with a history of opioid use disorder and their infants.
✕Less likely to help
Patients who are not pregnant or those without any history of opioid use may not benefit from this research.
What this research studies
This research focuses on understanding how maternal opioid use disorder affects fetal and placental health through advanced imaging techniques and biomarkers. It aims to identify early predictors of adverse outcomes for both mothers and infants exposed to opioids during pregnancy. By utilizing longitudinal and serial imaging, the study will assess changes in placental morphology and fetal development, providing insights into the risks associated with prenatal opioid exposure. The findings could lead to better management strategies for pregnant women with opioid use disorder and their infants.
Why it matters
Potential benefit: If successful, this research could lead to improved prediction and management of health outcomes for mothers and infants affected by opioid use during pregnancy.
How similar studies have gone: Previous studies have shown promising results in understanding the impacts of prenatal opioid exposure, indicating that this research builds on established findings.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Radhakrishnan, Rupa — Indiana University Indianapolis
- Study coordinator: Radhakrishnan, Rupa
Related research
Other NIH-funded projects on the same topics.
-
Systems analysis to improve opioid use disorder care after jail release (SAIA-MOUD)
A program to help people with opioid use disorder get better, faster, and safer care after they leave jail.
-
Precise epigenetic drugs for opioid addiction
A tiny, targeted drug approach is being developed to help people with opioid use disorder by rewriting the epigenetic signals in the brain to reduce cravings and relapse risk.
-
Increasing Access to Medications for Opioid Use Disorder for Unhoused Montanans
This project helps unhoused people in Montana get life-saving medicines for opioid use disorder through clinics connected to syringe service programs, a nurse-led MOUD model, and peer support.
-
Optimizing long-acting PrEP and opioid treatment for people in jails and prisons
This project tests a real-world approach to using long-acting PrEP and buprenorphine for HIV prevention and opioid treatment among incarcerated individuals and after release.
-
Scaling up medications for opioid use disorder in residential treatment programs
This grant studies how to help residential treatment programs provide medications for opioid use disorder to reduce overdoses after discharge, focusing on real-world settings and policies.
-
Increasing Capacity at a Native Community Clinic to Improve Opioid Care for urban AI/AN
This grant helps a Native American health clinic build its research capacity to better serve urban American Indian and Alaska Native people dealing with opioid use disorder and related health issues.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.