Investigating the effects of non-steroidal anti-inflammatory drugs on kidney health
Official title: Non-SteroidAl Impact on Kidney Disease Study (NSAIDS)
Funded at Northern California Institute/res/edu · NIH-11105810 · Data updated 2026-11-12
This study is looking at how common pain relievers called NSAIDs might affect your kidneys, especially if you have ongoing pain, and it aims to create a way to spot any early signs of kidney issues so that you can manage your pain safely.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | May 15, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $660,616 |
| NIH project number | 5R01DK132640-03 |
| Project ID | NIH-11105810 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults over 21 years old who experience chronic pain and may be at risk for kidney issues.
✕Less likely to help
Patients who do not experience chronic pain or have no risk factors for kidney disease may not benefit from this research.
What this research studies
This research focuses on understanding how non-steroidal anti-inflammatory drugs (NSAIDs) affect kidney function, particularly in adults with chronic pain. The study aims to develop a monitoring panel using urine and blood biomarkers to detect early signs of kidney toxicity caused by NSAIDs. By identifying specific sites of toxicity and forecasting potential declines in kidney function, the research seeks to provide safer pain management options for patients at risk of kidney damage. Patients will be monitored closely to ensure that any adverse effects on kidney health are caught early.
Why it matters
Potential benefit: If successful, this research could enable safer use of NSAIDs for pain management in patients with or at risk for chronic kidney disease.
How similar studies have gone: While the approach of using biomarkers for kidney monitoring is promising, it is relatively novel and has not been extensively tested in the context of NSAID use.
Where this research is happening
-
Northern California Institute/res/edu
San Francisco, United States Active
Researchers
- Principal investigator: Estrella, Michelle M — Northern California Institute/res/edu
- Study coordinator: Estrella, Michelle M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.