Investigating the effects of Nitro-Fatty Acids on heart disease
Nitro-Fatty Acids and Cardiovascular Disease
This study is looking at how a special type of fatty acid might help protect the hearts of people with diabetes by focusing on a protein that helps keep blood vessels healthy, with the goal of finding new ways to lower heart disease risk for these patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10862848 on NIH RePORTER |
What this research studies
This research focuses on understanding how Nitro-Fatty Acids can influence cardiovascular disease, particularly in patients with diabetes. It examines the role of a specific protein, TFEB, which helps regulate cellular processes like autophagy and inflammation in blood vessels. By studying these mechanisms, the research aims to identify new treatment strategies that could reduce the risk of heart disease in diabetic patients. The approach includes both laboratory experiments and animal models to gather comprehensive data on the effects of these compounds.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with diabetes who are at risk for cardiovascular disease.
Not a fit: Patients without diabetes or those who do not have cardiovascular disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly lower the risk of cardiovascular disease in diabetic patients.
How similar studies have performed: Previous research has shown promising results with similar approaches targeting endothelial function and inflammation in cardiovascular disease.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Chen, Yuqing Eugene — University of Michigan at Ann Arbor
- Study coordinator: Chen, Yuqing Eugene
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.