Investigating the effects of methamphetamine and HIV on brain cells using lab-grown models.
HIV, Methamphetamine and Human iPSC-derived Microglia-containing Cerebral Organoids
This study is looking at how methamphetamine use impacts brain health in people living with HIV, using special lab-grown brain models to better understand the effects and hopefully find new ways to help those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10834982 on NIH RePORTER |
What this research studies
This research focuses on understanding how methamphetamine (METH) abuse affects individuals with HIV, particularly regarding brain health. By using human induced pluripotent stem cells (iPSCs) to create brain-like structures called cerebral organoids, researchers aim to study the interactions between METH and HIV in the central nervous system. This innovative approach allows for a more accurate examination of how these substances contribute to neurocognitive disorders associated with HIV. The findings could lead to better prevention and treatment strategies for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who have a history of methamphetamine use.
Not a fit: Patients who do not have HIV or a history of methamphetamine use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for HIV-infected individuals who also struggle with methamphetamine addiction.
How similar studies have performed: Previous research has shown promise in using iPSC-derived models to study neurological conditions, indicating potential success for this novel approach.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Ho, Wenzhe — Temple Univ of the Commonwealth
- Study coordinator: Ho, Wenzhe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.