Investigating the effects of metformin on leg pain in older adults with poor blood flow
Metformin BenefIts Lower Extremities with Intermittent Claudication (MOBILE_IC)
This study is looking at how the diabetes medication metformin might help older adults with leg pain from poor blood flow, aiming to see if it can improve their walking and overall quality of life.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11044127 on NIH RePORTER |
What this research studies
This research focuses on how metformin, a common diabetes medication, can help older adults suffering from intermittent claudication, a condition that causes leg pain due to reduced blood flow. The study aims to assess the impact of metformin on improving walking ability and overall quality of life for patients with peripheral arterial disease. Participants will be monitored for changes in their symptoms and functional status over the course of the study. The approach includes both medical management and potential lifestyle modifications to enhance treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those over 65 years of age, who experience intermittent claudication due to peripheral arterial disease.
Not a fit: Patients who do not have peripheral arterial disease or those under 65 years of age may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new, effective treatment option for older adults with intermittent claudication, improving their mobility and quality of life.
How similar studies have performed: Previous research has shown that metformin can have beneficial effects on various age-related conditions, suggesting potential for success in this novel application.
Where this research is happening
Pittsburgh, United States
- Veterans Health Administration — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Tzeng, Edith — Veterans Health Administration
- Study coordinator: Tzeng, Edith
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.