Investigating the effects of memantine on cognitive function in individuals with Down syndrome
Down Syndrome Memantine Follow-up Study: EEG Data Analysis and Data Sharing with the Research Community
['FUNDING_R03'] · CASE WESTERN RESERVE UNIVERSITY · NIH-10876684
This study is looking at how a higher dose of the drug memantine might help improve thinking and learning skills in young people with Down syndrome by analyzing brain activity data from a past trial.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10876684 on ClinicalTrials.gov |
What this research studies
This research focuses on analyzing EEG data from a previous trial that tested the drug memantine in adolescents and young adults with Down syndrome. The study aims to explore the potential cognitive benefits of higher doses of memantine, which may not have been evident in earlier trials. By sharing this data with the broader research community, the project hopes to enhance understanding of how memantine affects brain activity and cognitive function in this population. Participants will be monitored for any changes in cognitive and adaptive skills as a result of the treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescents and young adults aged 15-32 with Down syndrome who are in generally good health.
Not a fit: Patients outside the age range of 15-32 or those with severe health complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for cognitive enhancement in individuals with Down syndrome.
How similar studies have performed: Previous studies have shown mixed results with memantine in similar populations, indicating that while this approach has been explored, the specific focus on higher doses in Down syndrome is relatively novel.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COSTA, ALBERTO C S — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: COSTA, ALBERTO C S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease biological marker, Alzheimer's disease patient