Investigating the effects of hormone therapy on heart health in transgender women
Official title: Cross Sex Steroid Therapy and Cardiovascular Risk in the Transgender Female
Funded at University of Mississippi Med Ctr · NIH-11074016 · Data updated 2026-11-12
This study is looking at how hormone therapy for transgender women might affect heart health, using a special animal model to help us understand the risks better, so we can find ways to keep people safe while they transition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project start | December 1, 2023 |
| Project end | March 3, 2025 |
| Funding year | 2025 |
| Award (this year) | $2,124 |
| NIH project number | 5F31HL172648-02 |
| Project ID | NIH-11074016 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are transgender females who are considering or currently undergoing Gender-Affirming Hormone Therapy.
✕Less likely to help
Patients who are not transgender or those who do not plan to undergo hormone therapy may not benefit from this research.
What this research studies
This research focuses on understanding the cardiovascular risks associated with Gender-Affirming Hormone Therapy (GAHT) in transgender females, who are individuals assigned male at birth but identify as female. The study uses a novel animal model to simulate the hormone therapy process, allowing researchers to observe the effects of estrogen and androgen suppression on heart health. By examining different rat strains, the research aims to uncover potential mechanisms that may contribute to increased cardiovascular risk in this population. The findings could lead to better management strategies for transgender individuals undergoing hormone therapy.
Why it matters
Potential benefit: If successful, this research could help identify ways to reduce cardiovascular risks for transgender women undergoing hormone therapy.
How similar studies have gone: While there is limited long-term research on cardiovascular risks in transgender individuals, this approach is novel and aims to fill a significant knowledge gap.
Where this research is happening
-
University of Mississippi Med Ctr
Jackson, United States Active
Researchers
- Principal investigator: Crudup, Breland — University of Mississippi Med Ctr
- Study coordinator: Crudup, Breland
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.