Investigating the effects of HIV and substance use on brain health
Omics Analyses of HIV and Substance Use Disorder
This study is looking at how HIV and substance use can affect the brain and lead to memory problems, like those seen in Alzheimer's, and it aims to find new ways to help improve mental health for people dealing with these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10666424 on NIH RePORTER |
What this research studies
This research explores how HIV and substance use disorders impact brain function and contribute to neurodegenerative diseases like Alzheimer's. By analyzing gene expression and other molecular changes in brain tissue from individuals with HIV, the study aims to uncover new therapeutic targets that could improve mental health outcomes. The research employs advanced techniques such as RNA sequencing and proteomics to gather comprehensive data on the biological mechanisms at play. Participants may help identify critical pathways that lead to cognitive decline in affected populations.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with HIV who also have a history of substance use and are experiencing cognitive decline.
Not a fit: Patients without HIV or substance use disorders, or those who do not exhibit cognitive impairment, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance cognitive function and quality of life for individuals living with HIV and substance use disorders.
How similar studies have performed: Previous research has shown promise in using omics approaches to understand neurodegenerative diseases, indicating that this methodology could yield valuable insights.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Repunte-Canonigo, Vez — Scripps Research Institute, the
- Study coordinator: Repunte-Canonigo, Vez
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.