Investigating the effects of HIV and opioids on brain cells
Uncovering HIV/opioid effects in the brain at the single cell level: transcription, chromatin accessibility, and reservoir analysis in the SIV/cART/morphine/rhesus monkey model
This study is looking at how HIV and opioid use impact brain cells, using advanced methods to learn more about their effects, which could help improve treatments for people dealing with these issues.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10877982 on NIH RePORTER |
What this research studies
This research explores how HIV and opioid abuse affect brain cells at a detailed level using advanced techniques like single-cell RNA sequencing. By studying nonhuman primates, the researchers aim to understand the interactions between HIV and opioids, focusing on specific brain cells that are crucial for understanding the disease and addiction. The project will analyze how these factors influence gene expression and cellular responses, providing insights that could lead to better treatments. The data generated will be shared with the scientific community to enhance knowledge in this area.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with HIV who also have a history of opioid use or addiction.
Not a fit: Patients who do not have HIV or opioid use issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for individuals affected by both HIV and opioid addiction.
How similar studies have performed: Other research has shown promising results in understanding the interactions between HIV and substance abuse, but this specific approach using single-cell analysis is relatively novel.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Fox, Howard S — University of Nebraska Medical Center
- Study coordinator: Fox, Howard S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.