Investigating the effects of HIV and antiretroviral therapy on low birth weight and mortality in children born to HIV-positive mothers.
HIV/ART, low birth weight, and mortality in HIV-exposed uninfected children: a translational mechanistic study
This study is looking at how being pregnant with HIV and taking treatment affects the health of babies, especially focusing on issues like low birth weight and survival rates, and it’s for women living with HIV and their little ones.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11077273 on NIH RePORTER |
What this research studies
This research examines how HIV and antiretroviral therapy (ART) during pregnancy affect the health of infants, particularly focusing on low birth weight and mortality rates. The study will follow a cohort of 600 women living with HIV and their infants, comparing them to a control group of HIV-negative women and their infants. Researchers will analyze biological samples to understand the mechanisms behind placental dysfunction and microbial changes that may contribute to adverse birth outcomes. The goal is to identify factors that increase the risk of low birth weight and improve health outcomes for these vulnerable children.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant women living with HIV who are receiving antiretroviral therapy, as well as their infants.
Not a fit: Patients who are not pregnant or who are HIV-negative may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing pregnancies in women living with HIV, ultimately enhancing the health and survival of their infants.
How similar studies have performed: Previous research has indicated that understanding the biological mechanisms of HIV and ART can lead to significant improvements in maternal and infant health outcomes, suggesting that this approach has potential for success.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Yotebieng, Marcel — Albert Einstein College of Medicine
- Study coordinator: Yotebieng, Marcel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.