Investigating the effects of Helicobacter pylori on stomach health and cancer risk
Official title: IMAGINE: Intestinal Metaplasia And Gastritis INtErception Study
Funded at Duke University · NIH-11040337 · Data updated 2026-11-12
This study is looking at how the bacteria Helicobacter pylori affects the stomach and can lead to serious issues like cancer, and it’s for people who have this infection to help find better ways to treat it and keep them healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | March 1, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $613,207 |
| NIH project number | 5R01DK135169-02 |
| Project ID | NIH-11040337 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with H. pylori infection or those showing signs of gastric intestinal metaplasia.
✕Less likely to help
Patients who do not have H. pylori infection or related gastric conditions may not benefit from this research.
What this research studies
This research focuses on understanding how the bacteria Helicobacter pylori affects the stomach lining and contributes to pre-malignant conditions. It aims to explore the relationship between different strains of H. pylori and the body's immune response, which can lead to complications such as gastric cancer. By analyzing the molecular characteristics of H. pylori and its interaction with the gastric mucosa, the study seeks to improve treatment strategies for H. pylori infections and prevent disease progression. Patients with H. pylori infection may be involved in this research to help identify factors that influence their health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for H. pylori infections and reduce the risk of gastric cancer in patients.
How similar studies have gone: Previous research has shown promise in understanding H. pylori's role in gastric diseases, but this study aims to provide novel insights into strain-specific factors and their implications for treatment.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Garman, Katherine — Duke University
- Study coordinator: Garman, Katherine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.