Investigating the effects of harmful chemicals on breast tissue development and cancer risk
Developing an in vitro to in vivo pipeline of mammary gland exposure-response relationships to per- and poly-fluoroalkyl substances (PFAS)
This study is looking at how certain chemicals known as 'forever chemicals' might affect breast tissue development and their possible connection to breast cancer, using special lab models to find out which ones are the most harmful, all while trying to limit animal testing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10889143 on NIH RePORTER |
What this research studies
This research focuses on understanding how per- and polyfluoroalkyl substances (PFAS), commonly known as 'forever chemicals', affect the development of mammary glands and their potential link to breast cancer. By creating advanced laboratory models that mimic breast tissue, researchers aim to identify which PFAS are most harmful and how they impact hormone-sensitive tissues. The study employs innovative imaging techniques to visualize changes in tissue structure and function, ultimately aiming to reduce the need for animal testing in environmental studies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals concerned about breast cancer risk, particularly those with known exposure to PFAS or living in contaminated areas.
Not a fit: Patients who are not exposed to PFAS or do not have a family history of breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of breast cancer linked to PFAS exposure.
How similar studies have performed: Previous research has shown promising results in using in vitro models to study the effects of environmental toxins, suggesting that this approach could yield valuable insights.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Oldenburg, Amy L — Univ of North Carolina Chapel Hill
- Study coordinator: Oldenburg, Amy L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.