Investigating the effects of genetic testing on hypertension, depression, and pain management.
Official title: IGNITE Cost Extension - Admin Supplement
Funded at University of Florida · NIH-10820198 · Data updated 2026-11-12
This study is looking at how getting genetic test results sooner or later can help African Americans with high blood pressure manage their condition better, and it also wants to see how genetic testing can improve treatment for those who don’t have certain genetic markers.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | August 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $1,351,790 |
| NIH project number | 3U01HG007269-09S2 |
| Project ID | NIH-10820198 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are African American adults with hypertension, with or without chronic kidney disease.
✕Less likely to help
Patients who do not have hypertension or are not of African ancestry may not benefit from this research.
What this research studies
This research focuses on two ongoing clinical trials that aim to understand how genetic testing can improve treatment outcomes for conditions like hypertension, depression, and pain management. The trials involve African American participants with hypertension, who will be randomly assigned to receive genetic test results either immediately or after a delay. By comparing these two groups, the research seeks to determine how early knowledge of genetic predispositions affects blood pressure control and treatment efficacy. Additionally, a pilot study will explore the impact of pharmacogenetic testing on managing blood pressure in those who test negative for specific genetic variants.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment strategies for hypertension, depression, and pain management, particularly for African American patients.
How similar studies have gone: Previous research has shown promising results in using genetic testing to guide treatment decisions, suggesting that this approach could be beneficial.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Cavallari, Larisa Humma — University of Florida
- Study coordinator: Cavallari, Larisa Humma
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.