Investigating the effects of folic acid on cancer risk in ulcerative colitis patients
Folic Acid Supplementation and Colitis-associated Colon Carcinogenesis
This study is looking at how taking folic acid might affect the risk of colorectal cancer in people with ulcerative colitis, especially for those with certain genetic changes, to better understand how it could influence tumor growth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst of Fox Chase Can Ctr NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11074126 on NIH RePORTER |
What this research studies
This research focuses on patients with ulcerative colitis, a condition that increases the risk of colorectal cancer. It examines how folic acid supplementation, which is often necessary due to folate deficiencies in these patients, may influence cancer development. The study aims to understand the mechanisms by which folic acid could potentially promote tumor growth in individuals with specific genetic mutations, particularly those affecting the p53 gene. Through advanced techniques like CRISPR and RNA sequencing, the research will explore the inflammatory pathways involved in this process.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have been diagnosed with ulcerative colitis.
Not a fit: Patients without ulcerative colitis or those who do not require folic acid supplementation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better preventive strategies for colorectal cancer in patients with ulcerative colitis.
How similar studies have performed: Preliminary studies have indicated that folic acid supplementation may increase cancer risk in similar contexts, suggesting that this research builds on existing findings.
Where this research is happening
Philadelphia, United States
- Research Inst of Fox Chase Can Ctr — Philadelphia, United States (Active)
Researchers
- Principal investigator: Clapper, Margie L. — Research Inst of Fox Chase Can Ctr
- Study coordinator: Clapper, Margie L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.