Investigating the effects of drugs like methamphetamine on HIV and brain health
Human/Animal Brain Chimera in drugs of abuse and HIV
This study is looking at how using methamphetamine affects people living with HIV, especially how it might impact their thinking and memory, to help find better ways to support their brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11088149 on NIH RePORTER |
What this research studies
This research explores how methamphetamine abuse impacts individuals living with HIV, particularly focusing on cognitive decline associated with HIV-Associated Neurocognitive Impairment (HAND). Using innovative humanized animal models, the study aims to understand the interactions between glial cells, methamphetamine, and the HIV reservoir in the brain. The research will assess how methamphetamine affects brain functions and the evolution of HIV over time, providing insights into potential therapeutic targets. By examining these mechanisms, the study seeks to improve understanding of the comorbidities faced by patients with HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who also have a history of methamphetamine abuse.
Not a fit: Patients who do not have HIV or a history of methamphetamine abuse may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cognitive decline in patients living with HIV who abuse methamphetamine.
How similar studies have performed: Previous research has shown promising results in understanding the interactions between drug abuse and HIV, but this specific approach using humanized animal models is relatively novel.
Where this research is happening
Chicago, United States
- Rush University Medical Center — Chicago, United States (Active)
Researchers
- Principal investigator: Al-Harthi, Lena — Rush University Medical Center
- Study coordinator: Al-Harthi, Lena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.