Investigating the effects of different radiation dose rates on tumors and normal tissues
Core B: Physics-Dosimetry Core
This study is looking at how different levels of radiation from treatments like proton, electron, and carbon therapies can help destroy tumors while keeping healthy tissue safe, using animal models to find the best ways to deliver these treatments accurately.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11030337 on NIH RePORTER |
What this research studies
This research focuses on understanding how varying radiation dose rates from proton, electron, and carbon therapies affect both tumor destruction and normal tissue damage. By using animal models, the team will deliver precise doses of radiation and monitor the outcomes. The study aims to establish a reliable dosimetry infrastructure that ensures consistent and accurate radiation delivery across different treatment modalities. This involves collaboration among radiation oncologists, biologists, and physicists to enhance treatment techniques and safety protocols.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with tumors that may benefit from advanced radiation therapies, particularly those involving proton or carbon radiation.
Not a fit: Patients who are not undergoing radiation therapy or those with conditions not suitable for animal model studies may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved radiation therapy techniques that minimize damage to healthy tissues while effectively targeting tumors.
How similar studies have performed: Previous research has shown promising results in using advanced radiation techniques, suggesting potential for significant advancements in treatment.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Diffenderfer, Eric S — University of Pennsylvania
- Study coordinator: Diffenderfer, Eric S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.