Investigating the effects of diesel exhaust and reduced blood flow on brain health
Synergistic white matter injury from diesel exhaust particulate and chronic cerebral hypoperfusion exposures: Interaction between the Nogo/NgR1 receptor pathway and extravascular fibrinogen toxicity
This study is looking at how breathing in diesel exhaust and having less blood flow to the brain might harm important brain areas that help us think, and it aims to find out how these factors affect the brain's ability to heal itself, which could help us understand and treat cognitive decline.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10591353 on NIH RePORTER |
What this research studies
This research explores how exposure to diesel exhaust particles and chronic reduced blood flow to the brain can lead to damage in white matter, which is crucial for cognitive function. By using animal models and cell cultures, the study aims to understand the interactions between these environmental factors and the brain's ability to repair itself. The researchers will specifically look at pathways that inhibit nerve growth and how certain proteins may contribute to brain injury and recovery. This work could provide insights into the mechanisms behind cognitive decline and potential therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with existing cerebrovascular diseases or cognitive impairments who may be affected by environmental factors like air pollution.
Not a fit: Patients without any history of cerebrovascular disease or cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect brain health and improve cognitive function in individuals affected by environmental pollutants and vascular issues.
How similar studies have performed: Previous studies have shown that environmental pollutants can adversely affect brain health, suggesting that this research could build on established findings.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Mack, William J — University of Southern California
- Study coordinator: Mack, William J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.