Investigating the effects of delayed blood flow restoration in childhood strokes
Official title: Hemorrhagic transformation associated with delayed reperfusion in perinatal and childhood ischemic stroke: brain maturation-dependent role of leukocytes
Funded at University of California, San Francisco · NIH-10811475 · Data updated 2026-11-12
This study is looking at how waiting too long to restore blood flow after a stroke affects the brains of kids and newborns, and it aims to find the best time to safely remove blood clots to help them recover better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 22, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $444,125 |
| NIH project number | 1R21NS131837-01A1 |
| Project ID | NIH-10811475 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and newborns who have experienced an ischemic stroke.
✕Less likely to help
Patients who have not experienced a stroke or are over the age of 21 may not benefit from this research.
What this research studies
This research explores how delayed restoration of blood flow after a stroke affects the brain in children and newborns. It focuses on understanding the role of immune cells in the brain during this process and aims to determine the safest timing for removing blood clots in pediatric stroke cases. By using experimental models, the study seeks to fill the knowledge gap regarding the optimal timing for treatment to minimize neurological damage. The findings could lead to improved treatment protocols for children suffering from ischemic strokes.
Why it matters
Potential benefit: If successful, this research could lead to better treatment strategies that reduce neurological damage in children who experience strokes.
How similar studies have gone: While there have been successful studies in adult stroke treatment, this research is exploring a relatively novel area in pediatric stroke management.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Vexler, Zinaida S — University of California, San Francisco
- Study coordinator: Vexler, Zinaida S
Related research
Other NIH-funded projects on the same topics.
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Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
-
EP2 blockers to protect the brain after a stroke
Aims to test brain-permeable EP2 antagonists to reduce damage after ischemic stroke and improve recovery.
-
Genetic testing to find causes of early-onset ischemic stroke
This project uses whole-exome sequencing to look for gene changes that may cause ischemic stroke in adults who had a stroke at a young age.
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Targeted nanomedicine to protect the brain after stroke
A targeted drug-delivery approach aims to boost blood-brain barrier repair and reduce brain damage after an acute ischemic stroke in patients at risk.
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How biological aging and blood proteins relate to thinking after a stroke
This project looks at whether measures of biological aging and patterns of blood proteins help explain which stroke survivors keep their thinking sharp and which go on to develop vascular dementia.
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Repurposing NEXLETOL to treat ischemic stroke
Aims to see if the cholesterol drug NEXLETOL can help people after an ischemic stroke by supporting brain energy use and reducing injury.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.