Investigating the effects of delayed blood flow restoration in childhood strokes
Hemorrhagic transformation associated with delayed reperfusion in perinatal and childhood ischemic stroke: brain maturation-dependent role of leukocytes
This study is looking at how waiting too long to restore blood flow after a stroke affects the brains of kids and newborns, and it aims to find the best time to safely remove blood clots to help them recover better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10811475 on NIH RePORTER |
What this research studies
This research explores how delayed restoration of blood flow after a stroke affects the brain in children and newborns. It focuses on understanding the role of immune cells in the brain during this process and aims to determine the safest timing for removing blood clots in pediatric stroke cases. By using experimental models, the study seeks to fill the knowledge gap regarding the optimal timing for treatment to minimize neurological damage. The findings could lead to improved treatment protocols for children suffering from ischemic strokes.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and newborns who have experienced an ischemic stroke.
Not a fit: Patients who have not experienced a stroke or are over the age of 21 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatment strategies that reduce neurological damage in children who experience strokes.
How similar studies have performed: While there have been successful studies in adult stroke treatment, this research is exploring a relatively novel area in pediatric stroke management.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Vexler, Zinaida S — University of California, San Francisco
- Study coordinator: Vexler, Zinaida S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.