Investigating the effects of COVID-19 on mental health in pregnant women

Cerebrospinal fluid (CSF) and peripheral markers of the neuropsychiatric sequelae of COVID-19: The Generation C-SF pregnancy study

NIH-funded research Icahn School of Medicine at Mount Sinai · NIH-11015041

This study is looking at how getting COVID-19 during pregnancy might impact the mental health and thinking skills of moms-to-be and new moms, so we can better understand their needs and provide them with the right support.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionIcahn School of Medicine at Mount Sinai NIH-funded
Lab location1 site (New York, United States)
Project IDNIH-11015041 on NIH RePORTER

What this research studies

This research focuses on understanding how COVID-19 infection affects the mental health and cognitive functions of pregnant and postpartum women. It aims to explore the long-term neuropsychiatric effects of SARS-CoV-2 infection during pregnancy, particularly how inflammation in the body and brain may contribute to these effects. By studying a large cohort of pregnant women, the research will analyze cerebrospinal fluid and other markers to identify potential risks and outcomes associated with COVID-19. The findings could help inform better care and support for affected women.

Who could benefit from this research

Good fit: Ideal candidates for this research are pregnant women who have been exposed to SARS-CoV-2, particularly those experiencing mental health challenges postpartum.

Not a fit: Patients who are not pregnant or who have not been infected with SARS-CoV-2 may not receive benefits from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved mental health interventions for pregnant women who have been infected with COVID-19.

How similar studies have performed: Other research has indicated significant neuropsychiatric effects of COVID-19 in the general population, suggesting that this approach could yield valuable insights for pregnant women as well.

Where this research is happening

New York, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions after COVID-19 infectionafter infection by SARS-CoV-2after SARS-CoV-2 infectionafter SARS-CoV2 infectionafter severe acute respiratory distress syndrome CoV-2 infection
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.