Investigating the effects of certain medications on Alzheimer's disease
Big data and small molecules for Alzheimer's disease
This study is looking at how certain heart medications, like ACE inhibitors, might affect the progression of Alzheimer's disease, using data from veterans to find patterns and testing these drugs to see if they can help reduce harmful proteins linked to the disease, which could lead to new treatment options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10992004 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific medications, particularly vasodilators like ACE inhibitors, may influence the progression of Alzheimer's disease (AD). By analyzing a vast database of medical records from veterans, the study aims to identify patterns in medication use and their potential impact on AD onset and progression. The research will also involve testing the effectiveness of these medications in reducing harmful proteins associated with AD in both human and animal models. Patients may benefit from insights that could lead to new treatment strategies for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include veterans diagnosed with mild cognitive impairment or various stages of Alzheimer's disease.
Not a fit: Patients who do not have Alzheimer's disease or mild cognitive impairment may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options that slow the progression of Alzheimer's disease and improve patient outcomes.
How similar studies have performed: Previous studies have shown promising results with similar approaches, particularly in the use of vasodilators for cognitive health.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Xia, Weiming — Boston University Medical Campus
- Study coordinator: Xia, Weiming
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.