Investigating the effects of certain HIV treatments and cocaine use on brain health.
Role of GRIN2 in ART and SUD associated neurological deficits.
This study is looking at how a common HIV treatment called integrase strand transfer inhibitors (INSTIs) works when someone also has a problem with cocaine use, and how this combination affects brain function, especially for people living with HIV who are dealing with substance use issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Meharry Medical College NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10898021 on NIH RePORTER |
What this research studies
This research focuses on understanding how integrase strand transfer inhibitors (INSTIs), a common treatment for HIV, interact with cocaine use disorders and their combined impact on brain function. The study aims to explore the neuropsychiatric side effects associated with these treatments, particularly in individuals living with HIV who also struggle with substance use. By examining the neuronal dysfunction caused by this combination, the research seeks to improve treatment strategies for better patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are undergoing treatment with INSTIs and have a history of cocaine use.
Not a fit: Patients who are not living with HIV or do not have a history of cocaine use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options that minimize neurological side effects for patients living with HIV who also use cocaine.
How similar studies have performed: While the specific combination of INSTIs and cocaine use has not been extensively studied, there is existing research on the neuropsychiatric effects of ART, indicating potential for significant findings.
Where this research is happening
Nashville, United States
- Meharry Medical College — Nashville, United States (Active)
Researchers
- Principal investigator: Dash, Chandravanu — Meharry Medical College
- Study coordinator: Dash, Chandravanu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.