Investigating the effects of cannabidiol on cannabis concentrate users
Official title: Cannabidiol and Cannabis Concentrate Users: A Randomized, Placebo Controlled Study
Funded at University of Colorado Denver · NIH-10912687 · Data updated 2026-11-12
This study is looking at how CBD might help people who often use strong cannabis products, and if you join, you'll try either CBD or a placebo for four weeks while using your usual cannabis, to see how it affects your experience and cravings.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $353,967 |
| NIH project number | 5P50DA056408-02 |
| Project ID | NIH-10912687 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults aged 21 and older who are frequent users of cannabis concentrates.
✕Less likely to help
Patients who do not use cannabis or who are not interested in cannabis products may not benefit from this research.
What this research studies
This research explores how cannabidiol (CBD) can impact individuals who frequently use high-THC cannabis concentrates. Participants will be recruited to take part in a four-week program where they will receive either CBD or a placebo while using cannabis concentrates. The study aims to assess the effects of CBD on cannabis use, subjective experiences, and cravings, utilizing a mobile pharmacology lab for data collection. By understanding the therapeutic potential of CBD, the research seeks to identify ways to mitigate the risks associated with high-THC products.
Why it matters
Potential benefit: If successful, this research could help reduce the negative effects of high-THC cannabis use and improve overall well-being for users.
How similar studies have gone: Previous studies have shown promising results regarding the effects of CBD on THC-related outcomes, indicating that this approach has potential for success.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Schacht, Joseph P. — University of Colorado Denver
- Study coordinator: Schacht, Joseph P.
Related research
Other NIH-funded projects on the same topics.
-
Hemp-derived CBD for reducing cannabis use in high-THC concentrate users
A randomized, placebo-controlled trial tests whether hemp-derived CBD can help adults who mainly use high-potency cannabis concentrates reduce their cannabis use.
-
Understanding how minority stress affects cannabis use in sexual minorities
A research project follows young adult sexual minorities to see how daily stress and coping help explain cannabis use and related problems.
-
Repeated cannabis with different THC/CBD mixes and how it affects pain, cravings, and body chemicals
This project studies how taking cannabis repeatedly, with different THC and CBD amounts, changes pain experiences, potential for abuse, and levels of body chemicals related to the endocannabinoid system in adults.
-
Terminal cannabinoid CB1 receptor changes in schizophrenia and cannabis use
This grant studies how cannabis use and schizophrenia together affect a brain receptor (CB1) and what that could mean for memory and symptoms.
-
Cannabis policies and prenatal cannabis use: how laws affect moms and babies
This grant studies how changes in recreational cannabis laws influence cannabis use during pregnancy and health outcomes for mothers and children.
-
Youth and social media marketing of hemp-derived cannabis products
Young people are increasingly exposed to hemp-derived cannabis product marketing on social media, and this study looks at how that marketing might influence their attitudes and curiosity.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.