Investigating the effects of brain injury on behavior and inflammation
Chronic behavioral outcome and neuroinflammatory consequences of TBI
['FUNDING_R01'] · VIRGINIA POLYTECHNIC INST AND ST UNIV · NIH-11089780
This study is looking at how brain injuries impact behavior and healing, especially by exploring how different immune cells from young and adult sources help the recovery process, with the goal of finding better treatments for people with traumatic brain injuries.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA POLYTECHNIC INST AND ST UNIV (nih funded) |
| Locations | 1 site (BLACKSBURG, UNITED STATES) |
| Trial ID | NIH-11089780 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how brain injuries affect behavior and lead to inflammation in the brain. It examines the role of different types of immune cells, particularly those derived from young and adult sources, in the healing process after traumatic brain injury (TBI). By using advanced techniques, including genetic models and behavioral assessments, the study aims to uncover the mechanisms that contribute to varying recovery outcomes based on age. The findings could help develop targeted therapies to improve recovery for individuals affected by brain injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who have experienced a traumatic brain injury.
Not a fit: Patients with brain injuries who are younger than 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance recovery and reduce long-term effects of brain injuries in patients.
How similar studies have performed: Previous research has shown promising results in understanding the immune response to brain injuries, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
BLACKSBURG, UNITED STATES
- VIRGINIA POLYTECHNIC INST AND ST UNIV — BLACKSBURG, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: THEUS, MICHELLE LEE — VIRGINIA POLYTECHNIC INST AND ST UNIV
- Study coordinator: THEUS, MICHELLE LEE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury