Investigating the effects of blood clots and oxygen levels during heart support treatment.
Official title: CLots and Oxygen in Va-ExtracorpoReal membrane oxygenation (CLOVER) study
Funded at Johns Hopkins University · NIH-11004087 · Data updated 2026-11-12
This study is looking at how the heart-lung machine used in severe heart failure treatment might cause blood clots and brain injuries, with the goal of finding ways to help patients have better brain health during and after their treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | January 21, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $138,226 |
| NIH project number | 5K23HL157610-04 |
| Project ID | NIH-11004087 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are receiving VA-ECMO for severe cardiac failure.
✕Less likely to help
Patients who are not undergoing VA-ECMO or those with pre-existing severe neurological conditions may not benefit from this research.
What this research studies
This research focuses on patients receiving Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO), a critical treatment for severe heart failure. It aims to understand how exposure to the ECMO circuit can lead to blood clots and how high oxygen levels may cause brain injuries. By examining these factors, the study seeks to identify potential interventions that could improve neurological outcomes for patients. The research involves monitoring patients' blood and brain health during and after ECMO treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing brain injuries in patients undergoing ECMO treatment.
How similar studies have gone: Previous research has indicated that managing blood clotting and oxygen levels can significantly impact patient outcomes in similar critical care settings.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Cho, Sung-Min — Johns Hopkins University
- Study coordinator: Cho, Sung-Min
Related research
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-
Identifying brain injury markers in critically ill children on ECMO.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.