Investigating the effects of bempedoic acid on cholesterol and inflammation in people living with HIV
Cholesterol and inflammation Lowering via BEmpedoic Acid, an ACL-inhibiting Regimen in HIV Trial (CLEAR HIV Trial)
This study is looking at how a medication called bempedoic acid can help improve heart health in people living with HIV who are at risk for heart disease, by comparing its effects to a placebo.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11145571 on NIH RePORTER |
What this research studies
This research focuses on individuals living with HIV who are at a higher risk for cardiovascular disease. It aims to evaluate the effects of bempedoic acid, a medication that lowers cholesterol and inflammation, on arterial health in these patients. Participants will be randomly assigned to receive either bempedoic acid or a placebo, with their arterial inflammation measured using advanced imaging techniques. The study seeks to understand how this treatment can improve cardiovascular health in those affected by HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 40 and older living with HIV who have either known cardiovascular disease or at least one cardiovascular risk factor.
Not a fit: Patients who are not living with HIV or those under 40 years of age may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cardiovascular health and reduced heart disease risk for people living with HIV.
How similar studies have performed: Previous research has shown promising results with similar approaches in managing cardiovascular risks in patients with HIV, indicating potential for success in this trial.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Hsue, Priscilla Y. — University of California Los Angeles
- Study coordinator: Hsue, Priscilla Y.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.