Investigating the effects of aspirin on childhood tuberculous meningitis
Official title: INTERCEPT
Funded at Stichting Radboud Universitair Medisch Centrum I.o. · NIH-11002699 · Data updated 2026-11-12
This study is looking at how tuberculous meningitis affects children and aims to find ways to predict their recovery and improve their chances of survival, including testing if aspirin can help reduce brain damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stichting Radboud Universitair Medisch Centrum I.o. NIH-funded |
| Lab location | 1 site (Nijmegen, Netherlands) |
| Project start | January 1, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $516,596 |
| NIH project number | 5R01AI165721-04 |
| Project ID | NIH-11002699 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include children diagnosed with tuberculous meningitis, particularly those experiencing severe symptoms or complications.
✕Less likely to help
Patients with other forms of meningitis or those who are not diagnosed with tuberculous meningitis may not benefit from this research.
What this research studies
This research focuses on understanding how tuberculous meningitis (TBM) affects children and explores the biological pathways that contribute to its high mortality and morbidity. By analyzing clinical, metabolomics, and genomics data, the study aims to identify markers that predict outcomes in pediatric TBM, similar to findings in adults. The research also examines the potential role of adjunctive aspirin therapy in reducing brain damage and improving survival rates in affected children. Patients may be involved in providing biological samples and clinical data to help uncover these critical insights.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for children suffering from tuberculous meningitis, potentially reducing mortality and long-term complications.
How similar studies have gone: Previous research has shown promising results in adult populations regarding the biological pathways involved in TBM, suggesting that similar approaches may yield valuable insights in children.
Where this research is happening
-
Stichting Radboud Universitair Medisch Centrum I.o.
Nijmegen, Netherlands Active
Researchers
- Principal investigator: Van Crevel, Reinout — Stichting Radboud Universitair Medisch Centrum I.o.
- Study coordinator: Van Crevel, Reinout
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.