Investigating the effects of aging on transplant procedures in animals
Official title: Microsurgery Core
Funded at Brigham and Women's Hospital · NIH-11083589 · Data updated 2026-11-12
This study is looking at how getting older affects the immune system and the success of transplant surgeries, using animals to help us learn more about the challenges older patients might face during these procedures.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 3, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $158,953 |
| NIH project number | 5P01AI175397-02 |
| Project ID | NIH-11083589 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older individuals who may require transplant procedures and are affected by age-related immune challenges.
✕Less likely to help
Patients who are not undergoing transplant procedures or are younger and not experiencing age-related complications may not benefit from this research.
What this research studies
This research focuses on understanding how aging affects the immune response and surgical outcomes in transplant procedures using animal models. The team of experts will perform microsurgical techniques while ensuring high standards of animal care and training. They aim to address challenges such as increased sensitivity to blood loss and anesthesia in older animals, which can impact the success of transplants. The project will also involve coordinating experiments, managing biological samples, and ensuring compliance with regulatory standards.
Why it matters
Potential benefit: If successful, this research could lead to improved transplant outcomes for older patients by enhancing our understanding of age-related challenges in surgery.
How similar studies have gone: Previous research has shown that understanding age-related effects in transplant procedures can lead to significant improvements in surgical outcomes, indicating a promising avenue for further exploration.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Tullius, Stefan Gunther — Brigham and Women's Hospital
- Study coordinator: Tullius, Stefan Gunther
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.