Investigating the effects of a specific protein from bacteria on gut health
Genotoxicity and immunogenicity of the uropathogenic specific protein (USP) in the gut
This study is looking at a protein from certain E. coli bacteria that might harm the gut, and it's for people interested in how this protein affects tiny lab-grown versions of their intestines, helping researchers learn more about gut health and the immune response.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Puerto Rico Med Sciences NIH-funded |
| Lab location | 1 site (San Juan, United States) |
| Project ID | NIH-11061081 on NIH RePORTER |
What this research studies
This research focuses on a protein called uropathogenic specific protein (USP) found in certain strains of E. coli, which may cause damage to the gut. The study aims to understand how this protein affects patient-derived intestinal organoids, which are miniaturized versions of the intestine created from patient cells. Researchers will explore the toxicity of USP, how it enters these organoids, and whether its presence in fecal samples is linked to an immune response. The work will be conducted by students, providing them with hands-on research experience.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of urinary tract infections or gastrointestinal issues related to bacterial pathogens.
Not a fit: Patients who do not have any gastrointestinal disorders or a history of urinary tract infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of intestinal disorders linked to bacterial infections.
How similar studies have performed: While the specific investigation of USP in the gut is novel, similar studies have shown that bacterial proteins can significantly impact gut health.
Where this research is happening
San Juan, United States
- University of Puerto Rico Med Sciences — San Juan, United States (Active)
Researchers
- Principal investigator: Baerga-Ortiz, Abel J — University of Puerto Rico Med Sciences
- Study coordinator: Baerga-Ortiz, Abel J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.