Investigating the effectiveness of random biopsies in patients with inflammatory bowel disease.
Official title: Utility of Random Biopsies in Inflammatory Bowel Disease
Funded at University of Pennsylvania · NIH-10855624 · Data updated 2026-11-12
This study is looking at how well random biopsies during colonoscopy can find early signs of cancer in people with inflammatory bowel diseases, helping to improve cancer screening for those at higher risk.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $2,410,980 |
| NIH project number | 1U01DK138901-01 |
| Project ID | NIH-10855624 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease who have been under surveillance for colorectal cancer.
✕Less likely to help
Patients who do not have inflammatory bowel disease or those who are not undergoing regular surveillance for colorectal cancer may not benefit from this research.
What this research studies
This research focuses on patients with inflammatory bowel diseases (IBD) who are at increased risk for colorectal cancer due to chronic inflammation. It aims to determine the effectiveness of random biopsies during colonoscopy in detecting precancerous lesions that may not be visible with standard techniques. The study will compare the outcomes of patients receiving random biopsies versus those receiving targeted biopsies, using advanced high-definition colonoscopy for better visualization. By evaluating the detection rates of dysplasia, the research seeks to establish more effective surveillance strategies for IBD patients.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for early detection of colorectal cancer in patients with inflammatory bowel disease.
How similar studies have gone: Previous research has shown that targeted biopsies may be more effective than random biopsies in detecting dysplasia, indicating that this area of investigation is both relevant and necessary.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Lewis, James D — University of Pennsylvania
- Study coordinator: Lewis, James D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.