Investigating the effectiveness of cooling therapy for newborns with brain injury
Advanced therapeutic hypothermia efficacy network modeling in neonatal HIE
This study is looking at how to make treatment better for newborns with brain injury from lack of oxygen by using cooling therapy, and it aims to find out which babies might need extra help by using data and advanced technology to predict how they will respond to the treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10873324 on NIH RePORTER |
What this research studies
This research focuses on improving the treatment of newborns suffering from hypoxic-ischemic encephalopathy (HIE) by using therapeutic hypothermia (TH). The team aims to enhance the understanding of how well TH works and identify which infants might benefit from additional therapies. By analyzing clinical data and molecular biomarkers through advanced computer modeling, they hope to predict individual responses to TH. This approach combines extensive data from health systems and community sources to create a comprehensive view of patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns diagnosed with hypoxic-ischemic encephalopathy who are receiving therapeutic hypothermia.
Not a fit: Patients who do not have hypoxic-ischemic encephalopathy or are outside the neonatal age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better-targeted therapies for newborns with brain injuries, potentially reducing long-term disabilities.
How similar studies have performed: Previous research has shown promise in using biomarkers and machine learning to improve treatment outcomes in similar conditions, indicating a potential for success in this approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Northington, Frances J — Johns Hopkins University
- Study coordinator: Northington, Frances J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.