Investigating the effectiveness of combining local therapy with standard treatment for recurrent prostate cancer in veterans
Official title: Veterans Affairs seamless phase II/III randomized trial of STAndard systemic theRapy with or without PET-directed local therapy for OligoRecurrenT prostate cancer (VA STARPORT)
Funded at Edward Hines Jr VA Hospital · NIH-11073061 · Data updated 2026-11-12
This study is looking at veterans with recurrent prostate cancer that has spread to a few places in the body, and it wants to see if adding local treatments like surgery or radiation to their usual hormone therapy can help them live longer and feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Edward Hines Jr VA Hospital NIH-funded |
| Lab location | 1 site (Hines, United States) |
| Project start | April 1, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01CX002277-05 |
| Project ID | NIH-11073061 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans diagnosed with oligorecurrent prostate cancer who have undergone initial local therapy and are experiencing recurrence.
✕Less likely to help
Patients with advanced metastatic prostate cancer involving multiple sites or those who have not received prior local therapy may not benefit from this research.
What this research studies
This research focuses on veterans with recurrent prostate cancer, specifically those with oligorecurrent disease, which means they have 1-5 sites of metastases. The study aims to evaluate whether adding local therapy, such as surgery or radiation, to standard systemic hormonal therapy can improve patient outcomes. By comparing the effectiveness of this combined approach against standard treatment alone, the research seeks to determine if it can lead to better disease control and potentially longer survival. Participants will be closely monitored for progression-free survival and overall health outcomes.
Why it matters
Potential benefit: If successful, this research could provide veterans with a more effective treatment option that may improve survival rates and quality of life.
How similar studies have gone: Previous studies have shown promising results with metastasis-directed therapy in similar patient populations, indicating potential for success in this approach.
Where this research is happening
-
Edward Hines Jr VA Hospital
Hines, United States Active
Researchers
- Principal investigator: Solanki, Abhishek Ashok — Edward Hines Jr VA Hospital
- Study coordinator: Solanki, Abhishek Ashok
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.