Investigating the differences in KRAS mutations in pancreatic cancer
Understanding Kras Mutation Heterogeneity in PDAC
This study is looking at how certain changes in the KRAS gene, especially the G12R mutation, affect the growth of pancreatic cancer, with the hope of finding better treatments for patients with these specific mutations.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10826535 on NIH RePORTER |
What this research studies
This research focuses on pancreatic ductal adenocarcinoma (PDAC), a highly lethal form of cancer characterized by specific mutations in the KRAS gene. The study aims to understand how different KRAS mutations, particularly the G12R variant, influence the development and progression of PDAC. By using advanced techniques like ATAC sequencing, researchers will explore the unique biological behaviors of these mutations in preclinical models. This could lead to better-targeted therapies for patients with specific KRAS mutations.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pancreatic ductal adenocarcinoma, particularly those with KRAS mutations.
Not a fit: Patients without pancreatic ductal adenocarcinoma or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments tailored to the specific KRAS mutations present in patients with pancreatic cancer.
How similar studies have performed: Other research has shown promising results in understanding KRAS mutations in various cancers, but the specific focus on the G12R mutation in PDAC is relatively novel.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Sisso, Whitney Juliet — Weill Medical Coll of Cornell Univ
- Study coordinator: Sisso, Whitney Juliet
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.