Investigating the differences in KRAS mutations in pancreatic cancer
Official title: Understanding Kras Mutation Heterogeneity in PDAC
Funded at Weill Medical Coll of Cornell Univ · NIH-10826535 · Data updated 2026-11-12
This study is looking at how certain changes in the KRAS gene, especially the G12R mutation, affect the growth of pancreatic cancer, with the hope of finding better treatments for patients with these specific mutations.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31CA288132-01 |
| Project ID | NIH-10826535 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with pancreatic ductal adenocarcinoma, particularly those with KRAS mutations.
✕Less likely to help
Patients without pancreatic ductal adenocarcinoma or those with other types of cancer may not benefit from this research.
What this research studies
This research focuses on pancreatic ductal adenocarcinoma (PDAC), a highly lethal form of cancer characterized by specific mutations in the KRAS gene. The study aims to understand how different KRAS mutations, particularly the G12R variant, influence the development and progression of PDAC. By using advanced techniques like ATAC sequencing, researchers will explore the unique biological behaviors of these mutations in preclinical models. This could lead to better-targeted therapies for patients with specific KRAS mutations.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments tailored to the specific KRAS mutations present in patients with pancreatic cancer.
How similar studies have gone: Other research has shown promising results in understanding KRAS mutations in various cancers, but the specific focus on the G12R mutation in PDAC is relatively novel.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Sisso, Whitney Juliet — Weill Medical Coll of Cornell Univ
- Study coordinator: Sisso, Whitney Juliet
Related research
Other NIH-funded projects on the same topics.
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-
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-
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-
Targeting autophagy to treat KRAS-mutant pancreatic cancer
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Reprogramming PDAC stroma by targeting blood clotting in the tumor environment
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-
Understanding paracrine signals in pancreatic cancer to improve drug delivery
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.