Investigating the differences in genetic crossover between male and female mice
Official title: Uncovering molecular factors driving sexual dimorphism in crossing over in diverse mouse genetic backgrounds
Funded at Cornell University · NIH-10890160 · Data updated 2026-11-12
This study looks at how male and female mice handle a key part of reproduction called genetic crossover, which helps ensure their chromosomes are sorted correctly, and it aims to find out why females have more crossovers even though they can make more mistakes, with the hope of learning more about chromosome issues that can affect humans.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project start | July 19, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $109,022 |
| NIH project number | 5K99HD112986-02 |
| Project ID | NIH-10890160 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of chromosomal abnormalities or reproductive issues, particularly those related to aneuploidy.
✕Less likely to help
Patients who do not have any reproductive health issues or chromosomal abnormalities may not benefit from this research.
What this research studies
This research explores how genetic crossover, a crucial process for proper chromosome segregation during reproduction, differs between male and female mice. It focuses on understanding the molecular factors that lead to these differences, particularly in the context of various mouse genetic backgrounds. By examining the formation of DNA double strand breaks and their repair mechanisms, the study aims to uncover why females tend to have higher crossover rates despite being more error-prone. This could provide insights into the underlying causes of chromosomal abnormalities in humans.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of chromosomal abnormalities, potentially improving reproductive health and outcomes for patients.
How similar studies have gone: While the specific focus on sexual dimorphism in crossover rates is novel, previous studies have successfully explored meiotic recombination and its implications for chromosomal abnormalities.
Where this research is happening
-
Cornell University
Ithaca, United States Active
Researchers
- Principal investigator: Horan, Tegan Sonia-Adeline — Cornell University
- Study coordinator: Horan, Tegan Sonia-Adeline
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.