Investigating the connection between traumatic brain injuries and Alzheimer's disease
Official title: TBI-ADRD Modeling with a Team Science Approach (TBI-ADRD Team Science)
Funded at Morehouse School of Medicine · NIH-10933960 · Data updated 2026-11-12
This study is creating a special mouse model to help us learn how traumatic brain injuries might lead to Alzheimer's and similar memory problems, so we can find better ways to understand and treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Morehouse School of Medicine NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 18, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $2,283,334 |
| NIH project number | 1RF1NS138029-01 |
| Project ID | NIH-10933960 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would be individuals with a history of traumatic brain injuries or those at risk for Alzheimer's disease.
✕Less likely to help
Patients who do not have a history of brain injuries or are not at risk for Alzheimer's disease may not receive any benefit from this research.
What this research studies
This research focuses on developing a mouse model to better understand how traumatic brain injuries (TBI) can lead to Alzheimer's disease and related dementias (ADRD). By employing a collaborative 'Team Science' approach, researchers from multiple sites will work together to enhance the reliability of their findings. They will systematically evaluate different mouse strains and types of brain injuries to identify factors that contribute to the progression of ADRD. The study aims to create a robust model that accurately reflects the complexities of human conditions, which could lead to improved understanding and treatment options.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for Alzheimer's disease and related dementias.
How similar studies have gone: Previous research has shown promise in using animal models to study the effects of brain injuries on neurodegenerative diseases, indicating that this approach could yield valuable insights.
Where this research is happening
-
Morehouse School of Medicine
Atlanta, United States Active
Researchers
- Principal investigator: Wang, Kevin Ka Wang — Morehouse School of Medicine
- Study coordinator: Wang, Kevin Ka Wang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.