Investigating the cellular structure of bowel tissue using advanced sequencing techniques
Data Analysis Core
This study is looking at the tiny building blocks of bowel tissue to learn more about how different cells work together, which could help improve our understanding of bowel health for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10886069 on NIH RePORTER |
What this research studies
This research focuses on understanding the cellular architecture of bowel tissue by generating detailed data at the single-cell level. Utilizing the Chromium Multiome platform, the team will perform simultaneous RNA and ATAC sequencing to analyze gene expression and regulatory mechanisms in various cell types. The study aims to identify both known and novel cell populations and will employ advanced imaging techniques to create three-dimensional maps of the tissue architecture. The data generated will be made publicly available to enhance community access and collaboration.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with bowel conditions or those interested in the cellular mechanisms of bowel tissue.
Not a fit: Patients without bowel conditions or those not interested in cellular biology may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of bowel tissue biology, potentially informing new treatments for bowel-related diseases.
How similar studies have performed: Previous research using similar multimodal sequencing approaches has shown promise in mapping complex tissue architectures, suggesting potential for success in this investigation.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Plevritis, Sylvia Katina — Stanford University
- Study coordinator: Plevritis, Sylvia Katina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.