Investigating the cellular mechanisms of vascular contributions to cognitive impairment and dementia.
Single-cell multi-region transcriptional and epigenomic dissection of VCID.
This study is looking at how blood vessel problems might affect memory and thinking in people with Alzheimer's and similar conditions, using brain samples to find new ways to diagnose and treat these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10532050 on NIH RePORTER |
What this research studies
This research focuses on understanding how vascular contributions to cognitive impairment and dementia (VCID) affect Alzheimer's disease and related dementias. By analyzing post-mortem brain samples, the study employs advanced techniques like single-nucleus RNA sequencing and DNA accessibility profiling to create a detailed atlas of transcriptional and epigenomic changes associated with VCID. The goal is to identify new biomarkers and therapeutic targets that could lead to better diagnosis and treatment options for patients suffering from these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease, vascular contributions to cognitive impairment, or related dementias.
Not a fit: Patients with non-vascular forms of cognitive impairment or those without any form of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new diagnostic tools and treatments for Alzheimer's disease and related dementias.
How similar studies have performed: Previous research has shown success in understanding vascular contributions to cognitive impairment, making this approach promising for further advancements.
Where this research is happening
Cambridge, United States
- Massachusetts Institute of Technology — Cambridge, United States (Active)
Researchers
- Principal investigator: Kellis, Manolis — Massachusetts Institute of Technology
- Study coordinator: Kellis, Manolis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.