Investigating the cellular diversity in white matter tracts of the brain in humans and primates
Cellular resolution multi-omics of white matter tracts in developing human and non-human primate brain for cell atlases-Diversity
This study is looking at the different types of cells in the brain's white matter to see how they relate to conditions like autism, and it’s for anyone interested in understanding how brain development affects thinking and learning.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11168653 on NIH RePORTER |
What this research studies
This research focuses on understanding the diversity of cell types in the white matter tracts of the brain, particularly in relation to cognitive disorders like autism spectrum disorder. By comparing human brain tissue with that of non-human primates, the study aims to profile gene expression and chromatin states at a single-cell level. This approach will help identify specific patterns of gene expression in oligodendrocytes, which are crucial for brain function and development. The research will involve analyzing various white matter tracts across different stages of development to gain insights into their role in cognitive capacity.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals under 21 years old diagnosed with autism spectrum disorder or related cognitive disorders.
Not a fit: Patients with cognitive disorders not related to autism spectrum disorder may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the biological underpinnings of autism spectrum disorder and other cognitive disorders, potentially informing new treatment strategies.
How similar studies have performed: Previous research has shown promising results in understanding brain cell diversity and its implications for cognitive disorders, making this approach both relevant and potentially impactful.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Konopka, Genevieve — Ut Southwestern Medical Center
- Study coordinator: Konopka, Genevieve
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.