Investigating the cellular and molecular mechanisms of Alzheimer's disease
A platform for cell type-level transcriptomic, epigenomic and spatial interrogation of Alzheimer's disease
This study is looking at how Alzheimer's disease affects different types of brain cells by examining brain tissue from people who have passed away, using advanced techniques to learn more about the disease and potentially find new ways to understand and treat it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Allen Institute NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10795072 on NIH RePORTER |
What this research studies
This research focuses on understanding Alzheimer's disease by using advanced molecular tools to analyze the genetic and epigenetic profiles of individual brain cells. By examining postmortem brain tissues, the study aims to identify specific cell types and their responses to the disease, which could reveal new insights into how Alzheimer's affects the brain. The approach combines traditional neuropathology with cutting-edge techniques like single nucleus transcriptomics and spatial transcriptomics to provide a detailed view of the disease's impact on various cell types.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease, particularly those at various stages of the condition.
Not a fit: Patients with other forms of dementia or neurological disorders unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets and strategies for treating Alzheimer's disease.
How similar studies have performed: Other research initiatives utilizing advanced molecular techniques have shown promise in understanding complex neurological diseases, suggesting that this approach could yield valuable insights as well.
Where this research is happening
Seattle, United States
- Allen Institute — Seattle, United States (Active)
Researchers
- Principal investigator: Lein, Ed — Allen Institute
- Study coordinator: Lein, Ed
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.