Investigating the causes of sudden infant death syndrome (SIDS) using a new animal model.
Official title: Central & Peripheral Mechanisms of Respiratory & Autonomic Control Dysfunction in a Novel Model of SIDS: Predictive Biomarkers and the Role of the Extracellular Matrix
Funded at Case Western Reserve University · NIH-10800086 · Data updated 2026-11-12
This study is looking into how low oxygen levels might affect babies' breathing and brain function to help find ways to prevent sudden infant death syndrome (SIDS).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | August 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $571,213 |
| NIH project number | 1R01HD111415-01A1 |
| Project ID | NIH-10800086 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants under one year of age who may be at risk for SIDS.
✕Less likely to help
Patients who are older than one year or those without risk factors for SIDS may not benefit from this research.
What this research studies
This research explores the mechanisms behind sudden infant death syndrome (SIDS) by using a novel rat model that simulates the critical conditions leading to SIDS. The study focuses on understanding how chronic exposure to low oxygen levels affects brainstem function and respiratory control in vulnerable infants. By examining the role of the extracellular matrix and specific brain abnormalities, researchers aim to identify predictive biomarkers that could help in preventing SIDS. The approach involves detailed observations and analyses of physiological changes in the animal model over time.
Why it matters
Potential benefit: If successful, this research could lead to the identification of biomarkers that help predict and prevent SIDS in infants.
How similar studies have gone: Previous studies using animal models have shown promise in understanding SIDS, but this specific approach is novel and aims to fill existing gaps in knowledge.
Where this research is happening
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Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Macfarlane, Peter — Case Western Reserve University
- Study coordinator: Macfarlane, Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.