Investigating the causes of sudden infant death syndrome (SIDS) using a new animal model.
Central & Peripheral Mechanisms of Respiratory & Autonomic Control Dysfunction in a Novel Model of SIDS: Predictive Biomarkers and the Role of the Extracellular Matrix
This study is looking into how low oxygen levels might affect babies' breathing and brain function to help find ways to prevent sudden infant death syndrome (SIDS).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10800086 on NIH RePORTER |
What this research studies
This research explores the mechanisms behind sudden infant death syndrome (SIDS) by using a novel rat model that simulates the critical conditions leading to SIDS. The study focuses on understanding how chronic exposure to low oxygen levels affects brainstem function and respiratory control in vulnerable infants. By examining the role of the extracellular matrix and specific brain abnormalities, researchers aim to identify predictive biomarkers that could help in preventing SIDS. The approach involves detailed observations and analyses of physiological changes in the animal model over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants under one year of age who may be at risk for SIDS.
Not a fit: Patients who are older than one year or those without risk factors for SIDS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the identification of biomarkers that help predict and prevent SIDS in infants.
How similar studies have performed: Previous studies using animal models have shown promise in understanding SIDS, but this specific approach is novel and aims to fill existing gaps in knowledge.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Macfarlane, Peter — Case Western Reserve University
- Study coordinator: Macfarlane, Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.