Investigating the causes of sporadic Alzheimer's disease
Temporal and spatial aspects of amyloidogenesis in sporadic Alzheimer disease
This study is looking at how the body struggles to clear a harmful protein linked to Alzheimer's disease in older adults, using special mouse models to find out what might cause this problem, with hopes of discovering new ways to help treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11091604 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms behind sporadic Alzheimer's disease (sAD), which affects many older adults. By using advanced mouse models, the study aims to explore how the clearance of amyloid beta protein is impaired, potentially leading to the development of Alzheimer's. The researchers will employ innovative techniques to temporarily block the clearance of this protein, allowing them to identify triggers that may contribute to the disease. The findings could pave the way for new therapeutic strategies to combat Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who may be at risk for developing Alzheimer's disease.
Not a fit: Patients who are younger than 65 or those with familial forms of Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve the management or prevention of Alzheimer's disease in older adults.
How similar studies have performed: While the approach of investigating amyloid beta clearance in sporadic Alzheimer's is innovative, similar studies have shown promise in understanding Alzheimer's pathology.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Leissring, Malcolm a — University of California-Irvine
- Study coordinator: Leissring, Malcolm a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.