NIH-funded research R01 grant

Investigating the causes of shoulder arthritis

Official title: Risk Factors for End-Stage Glenohumeral Osteoarthritis

Funded at Washington University · NIH-10857493 · Data updated 2026-11-12

This study is looking at what might increase the chances of developing shoulder arthritis, especially focusing on things we can change, like job activities, as well as things we can't change, like age and family history, to help find ways to prevent and treat this condition for people who might be at risk.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionWashington University
NIH-funded
Lab location1 site (Saint Louis, United States)
Project startSeptember 18, 2024
Project endJune 30, 2029
Funding year2024
Award (this year)$410,920
NIH project number1R01AR083937-01
Project IDNIH-10857493 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research include individuals at risk for glenohumeral osteoarthritis, particularly those with a history of shoulder instability or specific occupational exposures.

Less likely to help

Patients who do not have risk factors for shoulder arthritis or those with other unrelated shoulder conditions may not benefit from this research.

What this research studies

This research focuses on understanding the risk factors associated with glenohumeral osteoarthritis, a condition that can severely impact shoulder function. By examining both modifiable factors, such as occupation, and non-modifiable factors like age and genetics, the study aims to identify specific risks that lead to this type of arthritis. The research will utilize data from electronic medical records and genetic studies to provide insights that could guide prevention and treatment strategies for patients at risk. Ultimately, this work seeks to improve patient counseling and identify high-risk groups for early evaluation.

Why it matters

Potential benefit: If successful, this research could lead to better prevention strategies and treatment options for patients suffering from shoulder arthritis.

How similar studies have gone: While there has been significant research on osteoarthritis in other joints, this specific investigation into glenohumeral osteoarthritis is relatively novel and has not been extensively studied.

Where this research is happening

  • Washington University
    Saint Louis, United States
    Active

Researchers

  • Principal investigator: Yanik, Elizabeth Lee — Washington University
  • Study coordinator: Yanik, Elizabeth Lee

Related research

Other NIH-funded projects on the same topics.

  • Risk factors for shoulder osteoarthritis in adults

    This project looks at why some people develop painful shoulder osteoarthritis, especially as they age, and how factors like work, sex, and genetics influence the need for shoulder replacement.

    NIH research Washington University · Saint Louis, United States · NIH-11402777

  • Why some people get severe shoulder (glenohumeral) arthritis

    Researchers will look at personal, work, surgical, and genetic factors that make adults more likely to develop severe shoulder osteoarthritis that can lead to joint replacement.

    NIH research Washington University · Saint Louis, United States · NIH-11194274

  • Understanding how knee pain and knee obesity and muscle loss affect knee osteoarthritis

    This project looks at how knee swelling, excess knee fat, and muscle loss relate to pain and structural changes in knee osteoarthritis in adults.

    NIH research University of California, San Francisco · San Francisco, United States · NIH-11644470

  • IOP and CSF Pressure in Glaucoma Risk

    This grant studies how eye pressure and cerebrospinal fluid pressure together influence glaucoma risk and vision loss.

    NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11644421

  • ALS risk factors in a long-term ALS study

    A long-term ALS study is looking at which factors may influence disease risk and progression in people living with ALS.

    NIH research Als Therapy Development Foundation · Watertown, United States · NIH-11631679

  • Understanding how work exposures and genes influence ALS risk

    A study is building a long-term group of people at higher risk for ALS to see how their jobs, exposures at work, and genes together affect if and when the disease might develop.

    NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11631673

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.